Focus on knowledge creation

March 2021
The eTRANSAFE project on Translational Safety Assessment through Integrative Knowledge Management: Achievements and Perspectives. Pognan F, Steger‐Hartmann T, Díaz C, Blomberg N, Bringezu F, Briggs K, Callegaro G, Capella‐Gutierrez S, Centeno E, Corvi J, Drew P, Drewe WC, Fernández JM, Furlong LI, Guney E, Kors JA, Mayer MA, Pastor M, Piñero J, Ramírez‐Anguita JM, Ronzano F, Rowell P, Saüch‐Pitarch J, Valencia A, van de Water B, van der Lei J, van Mulligen E and Sanz F.
Pharmaceuticals

Knwoledge managementData miningDrug toxicityDrug safetyData sharing

February 2021
Guidelines for FAIR Sharing of Preclinical Safety and Off-Target Pharmacology Data.
Briggs K, Bosc N, Camara T, Díaz C, Drew P, Drewe WC, Kors J, van Mulligen E, Pastor M, Pognan F, Quintana JR, Sarntivijai S, Steger-Hartmann T.
ALTEX

PreclinicalData sharingOff-target pharmacologyFAIR

November 2019
Real-world evidence in Alzheimer’s disease: The ROADMAP Data Cube.
Janssen O, Vos SJB, Garcia-Negredo G, Tochel C, Gustavsson A, Smith M, Ly A, Nelson M, Baldwin H, Sudlow C, Bexelius C, Jindra C, Vaci N, Bauermeister S, Gallacher J, Ponjoan A, Dufoil C, Garre-Olmo J, Pedersen L, Skoog I, Hottgenroth A, Jelle-Visser P, van der Lei J, Díaz C.
Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association

AlzheimerData sharingRWEEHR

January 2019
Challenges for Optimizing Real-World Evidence in Alzheimer’s Disease: The ROADMAP Project.
Gallacher J, de Reydet de Vulpillieres F, Amzal B, Angehrn Z, Bexelius C, Bintener C, Bouvy JC, Campo L, Díaz C, Georges J, Gray A, Hottgenroth A, Jonsson P, Mittelstadt B, Potashman MH, Reed C, Sudlow C, Thompson R, Tockhorn-Heidenreich A, Turner A, van der Lei J, Jelle Visser P. Journal of Alzheimer’s Disease

AlzheimerData sharingRWEEHR

April 2018
A methodology for fine-grained access control in exposing biomedical data.
Trifan A, van der Lei J, Díaz C, Oliveira JL.
Studies in health technologies and informatics

Data exposureData privacyData sharing

October 2017
Legacy data sharing to improve drug safety assessment: the eTOX project.
Sanz F, Pognan F, Steger-Hartmann T, Díaz C, eTOX, Cases M, et al.
Nature Reviews Drug Discovery

Drug toxicityData sharing

May 2017
Inmunization in pregnancy clinical research in low -and middle- income countries- Study design, regulatory and safety considerations.
Kochhar S, Bonhoeffer J, Jones CE, Muñoz FM, Honrado A, Bauwens J, Sobanjo-ter Meulen A, Hirschfeld S.
Vaccine

Clinical trialsVaccination ImmunizationPregnancyInfectious diseases

June 2016
Making sense of big data in health research: Towards an EU action plan.
Auffray C, Balling R, Barroso I, Bencze L, Benson M, Bergeron J, et al.
Genome Medicine

Big dataHealth research Medical informatics

October 2016
Global alignment of immunization safety assessment in pregnancy – The GAIA project.
Bonhoeffer J, Kochhar S, Hirschfeld S, Heath PT, Jones CE, Bauwens J, Honrado A, Heininger U, Muñoz FM, Eckert L, Steinhoff M, Black S, Padula M, Sturkenboom M, Buttery J, Pless R, Zuber P for the GAIA project participants.
Vaccine

Clinical trialsVaccinationImmunizationPregnancyInfectious diseases

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December 2014
Guia de gestió projectes Horizon2020 (Guide for managing Horizon 2020 projects).
Honrado A, Molero E, Díaz C.
ACCIÓ-Agència per la Competitivitat de l’Empresa (Generalitat de Catalunya)

European projectsManagement Horizon2020

December 2013
Gathering and Exploring Scientific Knowledge in Pharmacovigilance.
Lopes P, Nunes T, Campos D, Furlong LI, Bauer-Mehren A, Sanz F, Carrascosa MC, Mestres J, Kors J, Singh B, van Mulligen E, Van der Lei J, Diallo G, Avillach P, Ahlberg E, Boyer S, Díaz C, Oliveira JL.
Public Library of Science (PLOS ONE) 

PharmacovigilanceADR Data mining

December 2012
The EU-ADR Web Platform: Delivering advanced pharmacovigilance tools.
Oliveira JL, Lopes P, Nunes T, Campos D, Boyer S, Ahlberg E, van Mulligen EM, Kors JA, Singh B, Furlong LI, Sanz F, Bauer-Mehren A, Carrascosa MC, Mestres J, Avillach P, Diallo G, Díaz C, van der Lei J.
Pharmacoepidemiology and Drug Safety

PharmacovigilanceEHR ADR

May 2012
Knowledge engineering for health: a new discipline required to bridge the “ICT gap” between research and healthcare.
Beck T, Gollapudi S, Brunak S, Graf N, Lemke HU, Dash D, Buchan I, Díaz C, Sanz F, Brookes AJ. 
Human Mutation

Knowledge engineeringVPH I4Health

February 2012
Electronic healthcare databases for active drug safety surveillance: is there enough leverage?
Coloma PM, Trifirò G, Schuemie MJ, Gini R, Hering R, Hippisley-Cox J, Mazzaglia G, Picelli G, Corrao G, Pedersen L, van der Lei J, Sturkenboom M, on behalf of the EU-ADR consortium.
Pharmacoepidemiology and Drug Safety

EHRDrug safetyDatabasesPharmacovigilance

January 2012
Automating classification of free-text electronic health records for epidemiological studies.
Schuemie MJ, Sen E, ‘t Jong GW, van Soest EM, Sturkenboom MC, Kors JA.
Pharmacoepidemiology and drug safety

EHRMachine learningData mining

May 2011
An Informatics Project and Online ‘‘Knowledge Centre’’ Supporting Modern Genotype-to-Phenotype Research.
Webb AJ, Thorisson GA, Brookes AJ, on behalf of the GEN2PHEN Consortium.
Human mutation

GenotypePhenotypeComputational biology

January 2011
Combining electronic healthcare databases in Europe to allow for large-scale drug safety monitoring: the EU-ADR Project.
Coloma P, Schuemie MJ, Trifirò G, Gini R, Herings R, Hippisley-Cox J, Mazzaglia G, Giaquinto C, Corrao G, Pedersen L, van der Lei J, Sturkenboom M, on behalf of the EU-ADR Consortium.
Pharmacoepidemiology and Drug Safety

EHRDrug safetyDatabases

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July 2010
In silico prediction of in vivo toxicity – the first steps of the e-Tox consortium.
Steger-Hartmann T, Pognan F, Sanz F, Díaz C, Sutter A, Pastor M.
Toxicology Letters

In vivoIn silicoDrug toxicity

March 2010
XGAP: a uniform and extensible data model and software platform for genotype and phenotype experiments.
Swertz MA, van der Velde KJ, Tesson BM, Scheltema RA, Arends D, Vera G, Alberts R, Dijkstra M, Schofield P, Schughart K, Hancock JM, Smedley D, Wolstencroft K, Goble C, de Brock EO, Jones AR, Parkinson HE, members of the Coordination of Mouse Informatics Resources (CASIMIR), Genotype-To-Phenotype (GEN2PHEN) Consortiums, Jansen RC.
Genome Biology

GenomicGeneticGenetic Association studiesGenotypePhenotype

December 2009
Data mining on electronic health record databases for signal detection in pharmacovigilance: which events to monitor?
Trifirò G, Pariente A, Coloma PM, Kors JA, Polimeni G, Miremont-Salamé G, Catania MA, Salvo F, David A, Moore N, Caputi AP, Sturkenboom M, Molokhia M, Hippisley-Cox J, Díaz C, van der Lei J, Fourrier-Reglat A, EU-ADR group.C.
Pharmacoepidemiology and Drug Safety

EHRDrug toxicityData mining

September 2009
In silico prediction of in vivo toxicities (eTox)—The Innovative Medicines Initiative Approach.
Steger-Hartmann T, Pognan F, Sanz F, Diaz C.
Toxicology Letters

In vivoIn silicoDrug toxicity

September 2009
The EU-ADR Project: Preliminary Results and Perspective.
Trifirò G, Fourrier-Reglat A, Sturkenboom MC, Díaz C, Van Der Lei J., EU-ADR Group.
Studies in health technologies and informatics

EHRDrug toxocityData mining

April 2009
Planning the Human Variome Project: The Spain Report.
Kaput J, Cotton RGH, Hardman L, Al Aqeel AI, Al-Aama JY, Al-Mulla F, et al.
Human Mutation

GenotypePhenotypePolymorphism

March 2008
Training Multidisciplinary Biomedical Informatics Students: Three Years of Experience.
van Mulligen EM, Cases M, Hettne K, Molero E, Weeber M, Robertson KA, Olivia B, de la Calle G, Maojo V.
Journal of the American Medical Informatics Association (JAMIA)

Medical informationData collectionEducation

Medical informationEducationGenomics

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2005
INFOBIOMED: European Network of Excellence on Biomedical Informatics to Support Individualised Healthcare.
Maojo V, de la Calle G, Martín-Sánchez F, Díaz C, Sanz F.
AMIA: Annual Symposium Proceedings

Medical informaticsMicrobiologyPilot projects

2005
The INFOBIOMED network of excellence: developments for facilitating training and mobility.
de la Calle G, Benito M, Moreno JL, Molero E.
Proceeding ISBMDA’05

Mobility Brokerage serviceBioinformaticsStatistics

January 2004
Biomedical Informatics: From Past Experiences to the Infobiomed Network of Excellence.
Maojo V, Martin-Sanchez F, Barreiro JM, Díaz C, Sanz F.
Lecture Notes in Computer Science

Medical informationBioinformatics

November 2002
LINK3D: secure linking of organisations involved in distributed drug discovery.
Díaz C, Blat J, González A, Herráiz C, Laurie B, Molero E, Palmer JLS, Pastor M, Patak A, Ramírez A, Sanz F, Soto D and the LINK3D Consortium.
Challenges and Achievements in E-business and E-work

Computer simulationDrug discovery

November 2002
Distant collaboration in drug discovery: the LINK3D project.
Pastor M, Benedetti P, Carotti A, Carrieri A, Díaz C, et al. LINK3D Consortium.
Journal of computer-aided molecular design

Computer simulationDrug design

September 2000
Information technology in community pharmacies for supporting responsible self-medication.
Sanz F, Silveira C, Díaz C, Alonso A, Loza MI, et al.
American Journal of Health-System Pharmacy

Community pharmacySelf-medicationStatistics

January 2000
New technologies for the marketing and sale of medicines on the Internet and television networks. Final Study.
Sanz F, Gaedt K, Alonso A, Díaz C.
European Parliament DG Research (Directorate A) The STOA Programme

Medical informationEducationGenomicsData collection

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