Focus on knowledge creation

March 2023
Participating in innovative medicines initiative funded neurodegenerative disorder projects—An impact analysis conducted as part of the NEURONET project. Hawksworth C, Salih F, Cresswell K, Steukers L, Diaz C, Killin L, Pradier L, Bradshaw A and Dawoud D. Frontiers in Neurology

Neurodegeneration Public-private partnership IMI JU

January 2023
The amyloid imaging for the prevention of Alzheimer’s disease consortium: A European collaboration with global impact. Collij LE, Farrar G, Valléz García D, Bader I, Shekari M, Lorenzini L, Pemberton H, Altomare D, Pla S, Loor M, Markiewicz P, Yaqub M, Buckley C, Frisoni GB, Nordberg A, Payoux P, Stephens A, Gismondi R, Visser PJ, Ford L, Schmidt M, Birck C, Georges J, Mett A, Walker Z, Boada M, Drzezga A, Vandenberghe R, Hanseeuw B, Jessen F, Schöll M, Ritchie C, Lopes Alves I, Gispert JD and Barkhof F, Frontiers in Neurology

Alzheimer’s disease Diagnosis Prognosis Amyloid

November 2022
Avoiding fragmentation: The potential of synergistic efforts across the IMI portfolio. Díaz C, Killin L, Hughes N. Front. Neurol. 2022; 13: 1050360.

Neurodegeneration Public-private partnership Data standardization Cohort studies Research platforms

November 2022
The Innovative Medicines Initiative neurodegeneration portfolio: From individual projects to collaborative networks. O’Rourke D, Coll-Padrós N, Bradshaw A, Killin L, Pradier L, Georges J, Dawoud DM, Steukers L and Díaz C.
Front. Neurol. – Sec. Dementia and Neurodegenerative Diseases 

Neurodegeneration Public-private partnership Research policy IMI

May 2022
The value of public‐private collaborative Real‐World Evidence platforms to monitor vaccine performance post authorization: DRIVE – a European initiative. Díez‐Domingo J, Torcel‐Pagnon L, Carmona A, Launay O, Dos Santo G, Rizzo C, Haag M, Stuurman A, Nauta J, Vannacci A, de Lusignan S, del Rey E, Levi M, Lina B, Bellino S, Nye S, Neels P, Nohynek H, Mahé C. Expert Review of Vaccines Journal

Vaccination Public-private partnership Influenza

March 2022
eTRANSAFE: Building a sustainable framework to share reproducible drug safety knowledge with the public domain. Sarntivijai S, Blomberg N, Lauer KB, Briggs K, Steger-Hartmann T, van der Lei J, Caves A, Sauer JM, Liwski R, Mourby M, Camprubi M, and the eTRANSAFE Consortium.  F1000Research 2022

Drug toxicity Drug safety Data sharing Data mining

March 2021
The eTRANSAFE Project on Translational Safety Assessment through Integrative Knowledge Management: Achievements and Perspectives. Pognan F, Steger‐Hartmann T, Díaz C, Blomberg N, Bringezu F, Briggs K, Callegaro G, Capella‐Gutierrez S, Centeno E, Corvi J, Drew P, Drewe WC, Fernández JM, Furlong LI, Guney E, Kors JA, Mayer MA, Pastor M, Piñero J, Ramírez‐Anguita JM, Ronzano F, Rowell P, Saüch‐Pitarch J, Valencia A, van de Water B, van der Lei J, van Mulligen E and Sanz F. Pharmaceuticals

Drug toxicity Drug safety Data sharing Knowledge

February 2021
Guidelines for FAIR Sharing of Preclinical Safety and Off‐Target Pharmacology Data*. Briggs K, Bosc N, Camara T, Díaz C, Drew P, Drewe WC, Kors J, van Mulligen E, Pastor M, Pognan F, Quintana JR, Sarntivijai S, Steger‐Hartmann T. ALTEX

Data sharing Preclinical FAIR Off-target pharmacology

November 2019
Real‐world evidence in Alzheimer’s disease: The ROADMAP Data Cube. Janssen O, Vos SJB, Garcia‐Negredo G, Tochel C, Gustavsson A, Smith M, Ly A, Nelson M, Baldwin H, Sudlow C, Bexelius C, Jindra C, Vaci N, Bauermeister S, Gallacher J, Ponjoan A, Dufoil C, Garre‐Olmo J, Pedersen L, Skoog I, Hottgenroth A, Jelle‐Visser P, van der Lei J, Díaz C. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association

Alzheimer Data sharing RWE EHR

January 2019
Challenges for Optimizing Real‐World Evidence in Alzheimer’s Disease: The ROADMAP Project. Gallacher J, de Reydet de Vulpillieres F, Amzal B, Angehrn Z, Bexelius C, Bintener C, Bouvy JC, Campo L, Diaz C, Georges J, Gray A, Hottgenroth A, Jonsson P, Mittelstadt B, Potashman MH, Reed C, Sudlow C, Thompson R, Tockhorn-Heidenreich A, Turner A, van der Lei J, Visser PJ, ROADMAP Consortium

Alzheimer’s disease Data sharing Data systems Health policy Patient Outcome assessment

April 2018
A methodology for fine‐grained access control in exposing biomedical data. Trifan A, van der Lei J, Díaz C, Oliveira JL. Studies in health technologies and informatics

Data exposure Data privacy Data sharing

October 2017
Legacy data sharing to improve drug safety assessment: the eTOX project. Sanz F, Pognan F, Steger‐Hartmann T, Díaz C, eTOX, Cases M, et al. Nature Reviews Drug Discovery

Drug toxicity Data sharing

July 2017
[P1–395]: AMYPAD: A European public-private partnership to investigate the value of β-amyloid brain scans as a diagnostic and therapeutic marker for Alzheimer’s disease. Farrar G, Barkhof F, Pla S, Gispert JD, Foley C, Mett A, Ritchie CW, Georges J, Stephens A, Schmidt ME, Van Der Geyten S, Frisoni GB.Alzheimer’s & Dementia, 13: P420-P420

Alzheimer’s Disease

May 2017
Immunization in pregnancy clinical research in low- and middle-income countries – Study design, regulatory and safety considerations . Kochhar S, Bonhoeffer J, Jones CE, Muñoz FM, Honrado A, Bauwens J, Sobanjo‐ter Meulen A, Hirschfeld S.Kochhar S, Bonhoeffer J, Jones CE, Muñoz FM, Honrado A, Bauwens J, Sobanjo‐ter Meulen A, Hirschfeld S. Vaccine

Clinical trials Vaccination Immunization Pregnancy

October 2016
Global alignment of immunization safety assessment in pregnancy – The GAIA project. Bonhoeffer J, Kochhar S, Hirschfeld S, Heath PT, Jones CE, Bauwens J, Honrado A, Heininger U, Muñoz FM, Eckert L, Steinhoff M, Black S, Padula M, Sturkenboom M, Buttery J, Pless R, Zuber P for the GAIA project

Clinical trials Vaccination Immunization Pregnancy

June 2016
Making sense of big data in health research: Towards an EU action plan. Auffray C, Balling R, Barroso I, Bencze L, Benson M, Bergeron J, et al. Genome Medicine

Big Data Health Research Medical Informatics

December 2014
Guia de gestió projectes Horizon2020 (Guide for managing Horizon 2020 projects). Honrado A, Molero E, Díaz C. ACCIÓ‐Agència per la Competitivitat de l’Empresa (Generalitat de Catalunya

European Projects Management Horizon2020

December 2013
Gathering and Exploring Scientific Knowledge in Pharmacovigilance. Lopes P, Nunes T, Campos D, Furlong LI, Bauer‐Mehren A, Sanz F, Carrascosa MC, Mestres J, Kors J, Singh B, van Mulligen E, Van der Lei J, Diallo G, Avillach P, Ahlberg E, Boyer S, Díaz C, Oliveira JL. Public Library of Science (PLOS ONE)

Pharmacovigilance ADR Data mining

December 2012
The EU‐ADR Web Platform: Delivering advanced pharmacovigilance tools. Oliveira JL, Lopes P, Nunes T, Campos D, Boyer S, Ahlberg E, van Mulligen EM, Kors JA, Singh B, Furlong LI, Sanz F, Bauer‐Mehren A, Carrascosa MC, Mestres J, Avillach P, Diallo G, Díaz C, van der Lei J. Pharmacoepidemiology and Drug Safety

Pharmacovigilance EHR ADR

May 2012
Knowledge engineering for health: a new discipline required to bridge the “ICT gap” between research and healthcare. Beck T, Gollapudi S, Brunak S, Graf N, Lemke HU, Dash D, Buchan I, Díaz C, Sanz F, Brookes AJ. Human Mutation

Knowledge engineering VPH I4Health

February 2012
Electronic healthcare databases for active drug safety surveillance: is there enough leverage? Coloma PM, Trifirò G, Schuemie MJ, Gini R, Hering R, Hippisley‐Cox J, Mazzaglia G, Picelli G, Corrao G, Pedersen L, van der Lei J, Sturkenboom M, on behalf of the EU‐ADR consortium. Pharmacoepidemiology and Drug Safety

EHR Drug safety Databases Pharmacovigilance

January 2012
Automating classification of free‐text electronic health records for epidemiological studies. Schuemie MJ, Sen E, ‘t Jong GW, van Soest EM, Sturkenboom MC, Kors JA. Pharmacoepidemiology and drug safety

EHR Machine learning Data mining

May 2011
An Informatics Project and Online ‘‘Knowledge Centre’’ Supporting Modern Genotype‐to‐phenotype research. Webb AJ, Thorisson GA, Brookes AJ, on behalf of the GEN2PHEN Consortium. Human mutation

Genotype Phenotype Computational biology

January 2011
Combining electronic healthcare databases in Europe to allow for large‐scale drug safety monitoring: the EU‐ADR Project. Coloma P, Schuemie MJ, Trifirò G, Gini R, Herings R, Hippisley‐Cox J, Mazzaglia G, Giaquinto C, Corrao G, Pedersen L, van der Lei J, Sturkenboom M, on behalf of the EU‐ADR Consortium. Pharmacoepidemiology and Drug Safety

EHR Drug safety Databases

July 2010
In silico prediction of in vivo toxicity ‐ the first steps of the e‐Tox consortium. Steger‐Hartmann T, Pognan F, Sanz F, Díaz C, Sutter A, Pastor M. Toxicology Letters

in vivo in silico Drug toxicity

March 2010
XGAP: a uniform and extensible data model and software platform for genotype and phenotype. Swertz MA, van der Velde KJ, Tesson BM, Scheltema RA, Arends D, Vera G, Alberts R, Dijkstra M, Schofield P, Schughart K, Hancock JM, Smedley D, Wolstencroft K, Goble C, de Brock EO, Jones AR, Parkinson HE, members of the Coordination of Mouse Informatics Resources (CASIMIR), Genotype‐To‐Phenotype (GEN2PHEN) Consortiums, Jansen RC. Genome Biology

Genomic  Genetic  Genetic Association studies Genotype Phenotype

December 2009
Data mining on electronic health record databases for signal detection in pharmacovigilance: which events to monitor? Trifirò G, Pariente A, Coloma PM, Kors JA, Polimeni G, Miremont‐Salamé G, Catania MA, Salvo F, David A, Moore N, Caputi AP, Sturkenboom M, Molokhia M, Hippisley‐Cox J, Díaz C, van der Lei J, Fourrier‐Reglat A, EU‐ADR group.C. Pharmacoepidemiology and Drug Safety

EHR  Drug toxicity  Data mining

September 2009
In silico prediction of in vivo toxicities (eTox)—The Innovative Medicines Initiative Approach. Steger‐Hartmann T, Pognan F, Sanz F, Diaz C. Toxicology Letters

in vivo  in silico  Drug toxicity 

September 2009
The EU-ADR Project: Preliminary Results and Perspective. Trifirò G, Fourrier-Reglat A, Sturkenboom MC, Díaz C, Van Der Lei J., EU-ADR Group. Studies in health technologies and informatics

EHR  Drug toxicity  Data mining 

April 2009
Planning the Human Variome Project: The Spain Report. Kaput J, Cotton RGH, Hardman L, Al Aqeel AI, Al‐Aama JY, Al‐Mulla F, et al. Human Mutation

Genotype  Phenotype  Polymorphism 

March 2008
Training Multidisciplinary Biomedical Informatics Students: Three Years of Experience. van Mulligen EM, Cases M, Hettne K, Molero E, Weeber M, Robertson KA, Olivia B, de la Calle G, Maojo V. Journal of the American Medical Informatics Association (JAMIA)

Medical information  Data collection  Education 

October 2007
Education and research in INFOBIOMED, the European Network of Excellence in Biomedical. De la Calle G, van Mulligen EM, Molero E, Perez‐Rey D, Martín L, Crespo J, Maojo V. AMIA: Annual Symposium Proceedings

Medical information  Education  Genomics

2005
INFOBIOMED: European Network of Excellence on Biomedical Informatics to Support Individualised. Maojo V, de la Calle G, Martín‐Sánchez F, Díaz C, Sanz F. AMIA: Annual Symposium Proceedings

Medical informatics  Microbiology  Pilot projects 

2005
The INFOBIOMED network of excellence: developments for facilitating training and mobility. De la Calle G, Benito M, Moreno JL, Molero E. Proceeding ISBMDA’05

Mobility Brokerage service  Bioinformatics  Statistics 

January 2004
Biomedical Informatics: From Past Experiences to the Infobiomed Network of Excellence. Maojo V, Martin‐Sanchez F, Barreiro JM,Díaz C, Sanz F. Lecture Notes in Computer Science

Medical information  Bioinformatics

November 2002
LINK3D: secure linking of organisations involved in distributed drug discovery. Diaz C, Blat J, González A, Herráiz C, Laurie B, Molero E, Palmer JLS, Pastor M, Patak A, Ramírez A, Sanz F, Soto D and the LINK3D Consortium. Challenges and Achievements in E‐business and E‐work

Computer simulation  Drug design

November 2002
Distant collaboration in drug discovery: the LINK3D project. Pastor M, Benedetti P, Carotti A, Carrieri A, Díaz C, et al. LINK3D Consortium. Journal of computer‐aided molecular design

Computer simulation  Drug design

September 2000
Information technology in community pharmacies for supporting responsible self‐medication. Sanz F, Silveira C, Díaz C, Alonso A, Loza MI, et al. American Journal of Health‐System Pharmacy

Community pharmacy  Self medication  Statistics 

January 2000
New technologies for the marketing and sale of medicines on the Internet and television networks. Final Study. Sanz F, Gaedt K, Alonso A, Díaz C. European Parliament DG Research (Directorate A) The STOA Programme

Medical information  Education  Genomics  Data Collection